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All posts; Tags Include "Pharmacology"
- June 1, 2017
- 12:59 AM
- 2,935 views
D10 in the Treatment of Prehospital Hypoglycemia: A 24 Month Observational Cohort Study
by Rogue Medic in Rogue Medic
Why treat hypoglycemia with 10% dextrose (D10), rather than the more expensive, potentially more harmful, and less available traditional treatment of 50% dextrose (D50)? Why not? The only benefit of 50% dextrose appears to be that it is what people are used to using, but aren't we used to starting IVs (IntraVenous lines) and running fluids through the IVs? ... Read more »
Hern, H., Kiefer, M., Louie, D., Barger, J., & Alter, H. (2016) D10 in the Treatment of Prehospital Hypoglycemia: A 24 Month Observational Cohort Study. Prehospital Emergency Care, 21(1), 63-67. DOI: 10.1080/10903127.2016.1189637
- March 31, 2017
- 08:00 AM
- 572 views
Friday Fellow: Mexican Giant Horsetail
by Piter Boll in Earthling Nature
by Piter Kehoma Boll If you are walking through the forest of Central America, you may end up finding something that at first you could think is a group of bamboos, plants growing as a cylindrical segmented stem that can … Continue reading →... Read more »
Revilla, M., Andrade-Cetto, A., Islas, S., & Wiedenfeld, H. (2002) Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients. Journal of Ethnopharmacology, 81(1), 117-120. DOI: 10.1016/S0378-8741(02)00053-3
- March 3, 2017
- 06:14 AM
- 543 views
Rare Disease Day – Findacure Scientific Conference: Drug Repurposing for Rare Diseases
by Joana Guedes in BHD Research Blog
This year’s Findacure Scientific Conference took place in London on Rare Disease Day and was again focused on Drug Repurposing for Rare Diseases. The conference brought together over 100 representatives from patient groups, researchers and members of the healthcare industry to discuss the importance and the latest developments in drug repurposing for rare diseases.... Read more »
Gijezen LM, Vernooij M, Martens H, Oduber CE, Henquet CJ, Starink TM, Prins MH, Menko FH, Nelemans PJ, & van Steensel MA. (2014) Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial. PloS one, 9(6). PMID: 24910976
- January 28, 2017
- 09:42 AM
- 1,061 views
Distortions of Reality
by The Neurocritic in The Neurocritic
President Trump this week repeated an assertion he made shortly after his election: that millions of ballots cast illegally by undocumented immigrants cost him the popular vote. If true, this would suggest the wholesale corruption of American democracy.
Not to worry: As far as anyone knows, the president’s assertion is akin to saying that millions of unicorns also voted illegally.
- In a
... Read more »
Preller, K., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., St?mpfli, P., Liechti, M., Seifritz, E., & Vollenweider, F. (2017) The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Current Biology. DOI: 10.1016/j.cub.2016.12.030
Wacker, D., Wang, S., McCorvy, J., Betz, R., Venkatakrishnan, A., Levit, A., Lansu, K., Schools, Z., Che, T., Nichols, D.... (2017) Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell, 168(3), 377-2147483647. DOI: 10.1016/j.cell.2016.12.033
- January 20, 2017
- 06:19 AM
- 752 views
RCC: Updates on Guidelines for Adjuvant Therapy and new drug combination
by Joana Guedes in BHD Research Blog
The European Association of Urology (EAU) Renal Cell Carcinoma (RCC) guidelines panel has recently updated its recommendation on adjuvant therapy with sunitinib in non-metastatic RCC after surgical tumour removal (Bex et al., 2016). These clinical guidelines provide urologists with evidence-based information and recommendations for the management of RCC and the panel includes urological surgeons, oncologists, pathologists, radiologists and patient advocates. Based on the conflicting results of t........ Read more »
Bex A, Albiges L, Ljungberg B, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB.... (2016) Updated European Association of Urology Guidelines Regarding Adjuvant Therapy for Renal Cell Carcinoma. European urology. PMID: 27986369
Meric-Bernstam, F., Tannir, N., Harding, J., Voss, M., Mier, J., DeMichele, A., Munster, P., Patel, M., Iliopoulos, O., Owonikoko, T.... (2016) Phase 1 study of CB-839, a small molecule inhibitor of glutaminase, in combination with everolimus in patients (pts) with clear cell and papillary renal cell cancer (RCC). European Journal of Cancer. DOI: 10.1016/S0959-8049(16)32626-0
- November 15, 2016
- 12:38 PM
- 819 views
Celebrex Boosts Antidepressant Response
by William Yates, M.D. in Brain Posts
I ran into an interesting article at ScienceDaily providing data on a small sample size study of the anti-inflammatory drug celecoxib (Celebrex) in depression.Access the ScienceDaily report on this study by clicking HERE.This study focused on subjects with bipolar depression. All subjects were in a depressed phase and received the antidepressant drug escitalopram (Lexapro).Although only 55 subjects participated in this study, the results were significant and large. Adding Celebrex to escitalopra........ Read more »
Savitz, J., Preskorn, S., Teague, T., Drevets, D., Yates, W., & Drevets, W. (2012) Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial. BMJ Open, 2(1). DOI: 10.1136/bmjopen-2011-000643
- November 4, 2016
- 06:00 AM
- 776 views
무료 슬롯머신 게임 2019Friday Fellow: Silvergreen Moss
by Piter Boll in Earthling Nature
by Piter Kehoma Boll Found throughout most of the world, you probably have encountered this fellow many times in your life, but did not pay any attention. After all, it is just a moss! Scientifically known as?Bryum argenteum and popularly … Continue reading →... Read more »
Sabovljevic, A., Sokovic, M., Sabovljevic, M., & Grubisic, D. (2006) Antimicrobial activity of Bryum argenteum. Fitoterapia, 77(2), 144-145. DOI: 10.1016/j.fitote.2005.11.002
Shaw, A., & Albright, D. (1990) Potential for the Evolution of Heavy Metal Tolerance in Bryum argenteum, a Moss. II. Generalized Tolerances among Diverse Populations. The Bryologist, 93(2), 187. DOI: 10.2307/3243622
- September 23, 2016
- 08:00 AM
- 840 views
Friday Fellow: Rosy Crust
by Piter Boll in Earthling Nature
by Piter Kehoma Boll If you are walking through a forest in Europe you may find the bark of some trees covered by a thin rosy or orange crust. Commonly known as rosy crust, its scientific name is?Peniophora incarnata. As … Continue reading →... Read more »
Lee, H., Yun, S., Jang, S., Kim, G., & Kim, J. (2015) Bioremediation of Polycyclic Aromatic Hydrocarbons in Creosote-Contaminated Soil by Peniophora incarnata KUC8836. Bioremediation Journal, 19(1), 1-8. DOI: 10.1080/10889868.2014.939136
Suay, I., Arenal, F,, Asensio, F. J., Basilio, A., Cabello, M. A., Díez, M. T., García, J. B., González del Val, A., Gorrochategui, J., Hernández, P.... (2000) Screening of basidiomycetes for antimicrobial activities. Antonie van Leeuwenhoek, 78(2), 129-140. DOI: 10.1023/A:1026552024021
- September 12, 2016
- 01:36 PM
- 763 views
Opioid Abuse: Treatment Guidelines
by William Yates, M.D. in Brain Posts
Molecular model of the drug buprenorphineThe U.S. Surgeon General recently sent a letter to all physicians about the danger of prescription opioids, particularly when used in combination with benzodiazepines (i.e. Valium, Xanax). This combination greatly increases the risk of overdose death.Clinicians can successfully assist those with opioid use disorders. Marc Schuckit, M.D. recently published a nice summary review of entitled "Treatment of Opioid-Use Disorder" in the New England Journal........ Read more »
Schuckit, M. (2016) Treatment of Opioid-Use Disorders. New England Journal of Medicine, 375(4), 357-368. DOI: 10.1056/NEJMra1604339
- September 9, 2016
- 01:10 PM
- 958 views
Statin Therapy: Rethinking Benefits and Risks
by William Yates, M.D. in Brain Posts
A recent 30-page manuscript provides an exhaustive review of the evidence for the efficacy and safety of statin therapy.The authors of this excellent review provide some context for the relative value of statins.The note that putting 10000 individuals with a history of a vascular event on a statin drug for 5 years would prevent 1,000 subsequent events. This is an example of secondary prevention--preventing another adverse outcome in those already experiencing an adverse event.But the statin drug........ Read more »
Collins, Rory, Reith, Christina, & Emberson, Jonathan. (2016) Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. info:/http://dx.doi.org/10.1016/S0140-6736(16)31357-5
- August 30, 2016
- 12:59 PM
- 834 views
Dyslexia Improvement in Medication Trial
by William Yates, M.D. in Brain Posts
Dyslexia or developmental reading disorder is a common learning disorder affecting about 5% of the school age population.Treatment of dyslexia is difficult and typically is focused on special education classes and reading exercises.Medication treatment for dyslexia is nearly unheard of as no FDA-approved drug is available for the condition.However, a recent randomized clinical drug trial found evidence to support the potential use of atomoxetine for dyslexia.Atomoxetine is a drug approved for at........ Read more »
Shaywitz S, Shaywitz B, Wietecha L, Wigal S, McBurnett K, Williams D, Kronenberger WG, & Hooper SR. (2016) Effect of Atomoxetine Treatment on Reading and Phonological Skills in Children with Dyslexia or Attention-Deficit/Hyperactivity Disorder and Comorbid Dyslexia in a Randomized, Placebo-Controlled Trial. Journal of child and adolescent psychopharmacology. PMID: 27410907
- August 19, 2016
- 08:00 AM
- 834 views
Friday Fellow: Asian Pigeonwing
by Piter Boll in Earthling Nature
by Piter Kehoma Boll Today’s Friday Fellow is a creeping (but not creepy) plant with nice deep blue flowers shaped like a human female genitalia. Yeah, you read that right. Its scientific name is?Clitoria ternatea, the genus name being a … Continue reading →... Read more »
Devi, B., Boominathan, R., & Mandal, S. (2003) Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root. Fitoterapia, 74(4), 345-349. DOI: 10.1016/S0367-326X(03)00057-1
Taranalli, A., & Cheeramkuzhy, T. (2011) Influence of Clitoria Ternatea Extracts on Memory and Central Cholinergic Activity in Rats. Pharmaceutical Biology, 38(1), 51-56. DOI: 10.1076/1388-0209(200001)3811-BFT051
- August 17, 2016
- 02:30 PM
- 931 views
The PROCAMIO Trial – IV Procainamide vs IV Amiodarone for the Acute Treatment of Stable Wide Complex Tachycardia
by Rogue Medic in Rogue Medic
This is a very interesting trial that may surprise the many outspoken amiodarone advocates, but it should not surprise anyone who pays attention to research.
ALPS showed that we should stop giving amiodarone for unwitnessed shockable cardiac arrest. The lead researcher is still trying to spin amiodarone for witnessed shockable cardiac arrest, even though the results do not show improvement in the one outcome that matters – leaving the hospital with a brain that still works.[1],[2],[3]... Read more »
Kudenchuk PJ, Brown SP, Daya M, Rea T, Nichol G, Morrison LJ, Leroux B, Vaillancourt C, Wittwer L, Callaway CW.... (2016) Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine, 374(18), 1711-22. PMID: 27043165
Ortiz M, Martín A, Arribas F, Coll-Vinent B, Del Arco C, Peinado R, Almendral J, & PROCAMIO Study Investigators. (2016) Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. European heart journal. PMID: 27354046
Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, Ruskin JN, & Ellinor PT. (2010) Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 17(3), 297-306. PMID: 20370763
Marill KA, deSouza IS, Nishijima DK, Stair TO, Setnik GS, & Ruskin JN. (2006) Amiodarone is poorly effective for the acute termination of ventricular tachycardia. Annals of emergency medicine, 47(3), 217-24. PMID: 16492484
Tomlinson DR, Cherian P, Betts TR, & Bashir Y. (2008) Intravenous amiodarone for the pharmacological termination of haemodynamically-tolerated sustained ventricular tachycardia: is bolus dose amiodarone an appropriate first-line treatment?. Emergency medicine journal : EMJ, 25(1), 15-8. PMID: 18156531
Ku?akowski P, Karczmarewicz S, Karpiński G, Soszyńska M, & Ceremuzyński L. (2000) Effects of intravenous amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2(3), 207-15. PMID: 11227590
Bonny A, De Sisti A, Márquez MF, Megbemado R, Hidden-Lucet F, & Fontaine G. (2012) Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia. World journal of cardiology, 4(10), 296-301. PMID: 23110246
Kowey PR. (1988) The calamity of cardioversion of conscious patients. The American journal of cardiology, 61(13), 1106-7. PMID: 3364364
- August 11, 2016
- 09:30 PM
- 924 views
Acupuncture vs intravenous morphine in the management of acute pain in the ED
by Rogue Medic in Rogue Medic
Should we have people providing "fake" acupuncture in the Emergency Department?
If so, how should we do this?
Since it is not the acupuncture, but the patient's reaction to the "ceremony of the placebo" that appears to be providing the pain relief, how many different ways might we vary the "treatment" to improve the placebo effect?... Read more »
Grissa, M., Baccouche, H., Boubaker, H., Beltaief, K., Bzeouich, N., Fredj, N., Msolli, M., Boukef, R., Bouida, W., & Nouira, S. (2016) Acupuncture vs intravenous morphine in the management of acute pain in the ED. The American Journal of Emergency Medicine. DOI: 10.1016/j.ajem.2016.07.028
Espay, A., Norris, M., Eliassen, J., Dwivedi, A., Smith, M., Banks, C., Allendorfer, J., Lang, A., Fleck, D., Linke, M.... (2015) Placebo effect of medication cost in Parkinson disease: A randomized double-blind study. Neurology, 84(8), 794-802. DOI: 10.1212/WNL.0000000000001282
Waber RL, Shiv B, Carmon Z, Ariely D. (2008) Commercial Features of Placebo and Therapeutic Efficacy. JAMA, 299(9), 1016. DOI: 10.1001/jama.299.9.1016
Ee, C., Xue, C., Chondros, P., Myers, S., French, S., Teede, H., & Pirotta, M. (2016) Acupuncture for Menopausal Hot Flashes. Annals of Internal Medicine, 164(3), 146. DOI: 10.7326/M15-1380
Cherkin, D., Sherman, K., Avins, A., Erro, J., Ichikawa, L., Barlow, W., Delaney, K., Hawkes, R., Hamilton, L., Pressman, A.... (2009) A Randomized Trial Comparing Acupuncture, Simulated Acupuncture, and Usual Care for Chronic Low Back Pain. Archives of Internal Medicine, 169(9), 858. DOI: 10.1001/archinternmed.2009.65
Goldman, R., Stason, W., Park, S., Kim, R., Schnyer, R., Davis, R., Legedza, A., & Kaptchuk, T. (2008) Acupuncture for Treatment of Persistent Arm Pain Due to Repetitive Use. The Clinical Journal of Pain, 24(3), 211-218. DOI: 10.1097/AJP.0b013e31815ec20f
- August 5, 2016
- 08:00 AM
- 950 views
Friday Fellow: Beggar’s tick
by Piter Boll in Earthling Nature
by Piter Kehoma Boll What if the cure for cancer has been living in your garden all this time and you have been trying to get rid of it because it is an annoying weed? I cannot assure you that … Continue reading →... Read more »
Brand?o, M., Krettli, A., Soares, L., Nery, C., & Marinuzzi, H. (1997) Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. Journal of Ethnopharmacology, 57(2), 131-138. DOI: 10.1016/S0378-8741(97)00060-3
Chang, J., Chiang, L., Chen, C., Liu, L., Wang, K., & Lin, C. (2001) Antileukemic Activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb. The American Journal of Chinese Medicine, 29(02), 303-312. DOI: 10.1142/S0192415X01000320
Chiang, L., Chang, J., Chen, C., Ng, L., & Lin, C. (2003) Anti-Herpes Simplex Virus Activity of Bidens pilosa and Houttuynia cordata. The American Journal of Chinese Medicine, 31(03), 355-362. DOI: 10.1142/S0192415X03001090
Deba, F., Xuan, T., Yasuda, M., & Tawata, S. (2008) Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control, 19(4), 346-352. DOI: 10.1016/j.foodcont.2007.04.011
Kviecinski, M., Felipe, K., Schoenfelder, T., de Lemos Wiese, L., Rossi, M., Gon?alez, E., Felicio, J., Filho, D., & Pedrosa, R. (2008) Study of the antitumor potential of Bidens pilosa (Asteraceae) used in Brazilian folk medicine. Journal of Ethnopharmacology, 117(1), 69-75. DOI: 10.1016/j.jep.2008.01.017
Oliveira, F., Andrade-Neto, V., Krettli, A., & Brand?o, M. (2004) New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. Journal of Ethnopharmacology, 93(1), 39-42. DOI: 10.1016/j.jep.2004.03.026
Pereira, R., Ibrahim, T., Lucchetti, L., da Silva, A., & de Moraes, V. (1999) Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L. Immunopharmacology, 43(1), 31-37. DOI: 10.1016/S0162-3109(99)00039-9
Sun, Y., Zhou, Q., Wang, L., & Liu, W. (2009) Cadmium tolerance and accumulation characteristics of Bidens pilosa L. as a potential Cd-hyperaccumulator. Journal of Hazardous Materials, 161(2-3), 808-814. DOI: 10.1016/j.jhazmat.2008.04.030
- July 22, 2016
- 10:01 AM
- 833 views
Update on clinical trials and treatments for RCC
by Joana Guedes in BHD Research Blog
Renal cell carcinoma (RCC) is the most common type of kidney cancer and although the majority of cases are sporadic approximately 3% of cases are caused by genetic conditions such as BHD, VHL, HLRCC and TSC (Randall et al., 2014). These inherited forms of RCC have provided great insights into sporadic cancer genetics. BHD patients can develop multiple kidney tumours. In most cases these tumours are small local RCCs that can be surgically removed. However, these treatments are not without risk,........ Read more »
Randall JM, Millard F, & Kurzrock R. (2014) Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art. Cancer metastasis reviews, 33(4), 1109-24. PMID: 25365943
- July 14, 2016
- 02:27 PM
- 1,037 views
Weird stuff found in recreational drugs: Cocaine edition
by Rosin Cerate in Rosin Cerate
This is the fifth and final post in a series on strange substances accidentally or intentionally added to street drugs. When you're done here, check out the posts on alcohol, meth, opioids, and pot/LSD.If a drug is being sold illegally, chances are its sellers have added crap to it in order to make more money. Cocaine is no exception to this deception. Substances added to nose candy because they resemble the drug but otherwise don't mimic or influence its effects include talc powder, flour, corn........ Read more »
Tallarida CS, Tallarida RJ, & Rawls SM. (2015) Levamisole enhances the rewarding and locomotor-activating effects of cocaine in rats. Drug and Alcohol Dependence, 145-150. PMID: 25683823
- July 12, 2016
- 12:36 PM
- 754 views
Dextromethorphan for Alzheimer's Disease Agitation
by William Yates, M.D. in Brain Posts
In my last post I summarized a review of the pharmacology of the drug dextromethorphan.This drug is receiving significant attention for disorders in neuroscience medicine. A phase 2 clinical trial of dextromethorphan-quinidine (DM-Q) was published last fall in JAMA.Here are the key design and results from this study:Subjects: 220 subjects with a diagnosis of probable Alzheimer's disease with clinically significant agitation.Randomization Design: This was a five week trial of 3:4 random........ Read more »
Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, De La Gandara JE, Agronin M, Davis CS, Nguyen U.... (2015) Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA, 314(12), 1242-54. PMID: 무료 슬롯머신 게임 201926393847
- July 11, 2016
- 12:41 PM
- 874 views
When Laughing Isn't Funny
by William Yates, M.D. in Brain Posts
Inappropriate uncontrollable laughing or crying is common in many neuroscience medicine disorders including after traumatic brain injury or stroke. It can be socially embarrassing and restrict opportunities for social interaction.This loss of control over emotional responses is known by the term pseudobulbar affect or PBA. Until recently, few therapeutic options were available to treat this condition. Now a relatively new drug Nuedexta uses a combination of dextromethorphan and quinide to treat ........ Read more »
Taylor CP, Traynelis SF, Siffert J, Pope LE, & Matsumoto RR. (2016) Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta?) clinical use. Pharmacology . PMID: 27139517
- June 15, 2016
- 11:18 AM
- 952 views
Weird stuff found in recreational drugs: Meth edition
by Rosin Cerate in Rosin Cerate
As Breaking Bad has taught us, the clandestine manufacture of methamphetamine is a very dangerous undertaking. It involves the use of many harmful substances, which depending on the synthesis method include highly corrosive acids and bases, cancer-causing benzene, brain-damaging mercury and lead, jaw-wrecking phosphorus, and blood-breaking sodium cyanide. Blending these various substances together can produce noxious fumes, making gas masks and chemical suits a necessity if you want to avoid get........ Read more »
Cole C, Jones L, McVeigh J, Kicman A, Syed Q, & Bellis M. (2011) Adulterants in illicit drugs: A review of empirical evidence. Drug Testing and Analysis, 3(2), 89-96. PMID: 21322119
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